For an oocyte to become ready for fertilization and expansion into an embryo, the correct set of genes ought to be turned on. Namekawa suspected this pre-programming with the oocyte genome transpires in a number of stages — the very first one starting off around the time a female is born. He believed that chromatin remodeling proteins did Substantially of this function, by shifting spools around.
“Our intention is to understand woman reproductive getting old, and why fertility fast declines starting in the mid-30s,” suggests Satoshi Namekawa, a professor of Microbiology and Molecular Genetics, in whose lab Munakata works.
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Namekawa thinks that in human oocytes, modifications in these styles could disrupt the delicate choreography of genes staying turned on and off at the proper times — leaving them unprepared for fertilization or expansion into wholesome embryos. Variations in chromatin construction as an oocyte ages may also influence how that chromosomes segregate throughout mobile division.
This protein may well “establish and sustain the chromatin point out,” says Namekawa — trying to keep the spools set up and also the oocytes genetically primed as being the mouse matures.
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